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Firecrawl Alexandria
Health

Open Targets Platform

Drug-target evidence from the Open Targets Platform (EMBL-EBI, Wellcome Sanger Institute and partners; data CC0): target profiles with tractability, safety liabilities and cross-references; diseases and phenotypes across EFO, MONDO, HP and Orphanet with synonyms and vocabulary mappings; target-disease association scores broken down by evidence type and datasource; the evidence records behind them (GWAS, rare variants, somatic drivers, clinical precedence, literature); and known drugs and clinical candidates with mechanisms, clinical stage and trial or regulatory references. Targets resolve from symbols, synonyms and UniProt accessions, diseases from names and IDs, including retired EFO IDs. Uses the keyless Open Targets GraphQL API.

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Is BRAF tractable with small molecules or antibodies, and what safety liabilities are known?

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Open Targets Platform
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1Request
string

`next_cursor` from the previous page. Repeat the same inputs and `limit` with it.

string

Disease or phenotype: an ontology ID (`MONDO_0004979`, `EFO_0000270`, `EFO:0000270`, `HP_0002099`, `Orphanet_558`), an exact name or exact synonym (`asthma`, `T2DM`), or a platform.opentargets.org disease page URL. Retired EFO IDs follow to their replacement with a `disease_replaced` warning; other names fail as not_found listing the closest matches (use `search_diseases` to browse).

boolean

Include indirect evidence, which propagates evidence on a disease's descendants up to it (e.g. Crohn's disease evidence counts for inflammatory bowel disease). Defaults to false for a target's diseases and true when a disease is given, as on the Open Targets pages.

number

Rows per page, 1 to 100.

string

Target: an HGNC symbol (`BRAF`), Ensembl gene ID (`ENSG00000157764`), UniProt accession (`P15056`), previous symbol, synonym (`HER2`, `p53`), approved name, or a platform.opentargets.org target page URL. Ambiguous synonyms fail as invalid_input naming the candidates.

5 credits
Codefollows the fields above
const result = await firecrawl.scrape({
  alexandria: {
    provider: "platform-opentargets-org",
    capability: "associations/list_associations",
    options: {
      limit: 10,
      target: "BRAF",
    },
  },
});
2Response example

This is a sample shape. Press Run to see live data from Open Targets Platform.

{
  "disease": null,
  "indirect": false,
  "license": {
    "attribution": "Open Targets Platform, release 26.09 (https://platform.opentargets.org). Cite: Buniello A. et al. Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery. Nucleic Acids Res. 2025;53(D1):D1467-D1475. doi:10.1093/nar/gkae1128",
    "name": "CC0 1.0",
    "url": "https://creativecommons.org/publicdomain/zero/1.0/"
  },
  "min_score": null,
  "next_cursor": "10",
  "observed_at_ms": 1792530868500,
  "order_by": "score",
  "release": "26.09",
  "results": [
    {
      "datasource_scores": [
        {
          "datasource": "uniprot_variants",
          "score": 0.9794
        },
        {
          "datasource": "genomics_england",
          "score": 0.9611
        },
        {
          "datasource": "eva",
          "score": 0.9528
        },
        {
          "datasource": "reactome",
          "score": 0.8275
        },
        {
          "datasource": "clingen",
          "score": 0.6079
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "orphanet",
          "score": 0.6079
        },
        {
          "datasource": "uniprot_literature",
          "score": 0.6079
        },
        {
          "datasource": "europepmc",
          "score": 0.5315
        },
        {
          "datasource": "impc",
          "score": 0.452
        },
        {
          "datasource": "eva_somatic",
          "score": 0
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_association",
          "score": 0.9442
        },
        {
          "datatype": "genetic_literature",
          "score": 0.856
        },
        {
          "datatype": "affected_pathway",
          "score": 0.8275
        },
        {
          "datatype": "literature",
          "score": 0.5315
        },
        {
          "datatype": "animal_model",
          "score": 0.452
        },
        {
          "datatype": "somatic_mutation",
          "score": 0
        }
      ],
      "disease_id": "MONDO_0015280",
      "disease_name": "cardiofaciocutaneous syndrome",
      "ensembl_id": "ENSG00000157764",
      "score": 0.877,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0015280",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "genetic, familial or congenital disease",
        "integumentary system disorder",
        "cardiovascular disorder",
        "musculoskeletal or connective tissue disease"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "genomics_england",
          "score": 0.9331
        },
        {
          "datasource": "reactome",
          "score": 0.9191
        },
        {
          "datasource": "eva",
          "score": 0.9032
        },
        {
          "datasource": "uniprot_variants",
          "score": 0.8898
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "orphanet",
          "score": 0.6079
        },
        {
          "datasource": "uniprot_literature",
          "score": 0.6079
        },
        {
          "datasource": "impc",
          "score": 0.4383
        },
        {
          "datasource": "clingen",
          "score": 0.304
        },
        {
          "datasource": "europepmc",
          "score": 0.1247
        }
      ],
      "datatype_scores": [
        {
          "datatype": "affected_pathway",
          "score": 0.9191
        },
        {
          "datatype": "genetic_association",
          "score": 0.8767
        },
        {
          "datatype": "genetic_literature",
          "score": 0.823
        },
        {
          "datatype": "animal_model",
          "score": 0.4383
        },
        {
          "datatype": "literature",
          "score": 0.1247
        }
      ],
      "disease_id": "MONDO_0018997",
      "disease_name": "Noonan syndrome",
      "ensembl_id": "ENSG00000157764",
      "score": 0.8381,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0018997",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "cardiovascular disorder",
        "genetic, familial or congenital disease",
        "hematologic disorder",
        "integumentary system disorder",
        "immune system disorder",
        "musculoskeletal or connective tissue disease",
        "phenotype"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "europepmc",
          "score": 0.9984
        },
        {
          "datasource": "clinical_precedence",
          "score": 0.9778
        },
        {
          "datasource": "intogen",
          "score": 0.9118
        },
        {
          "datasource": "eva",
          "score": 0.6991
        },
        {
          "datasource": "cancer_gene_census",
          "score": 0.6079
        },
        {
          "datasource": "crispr",
          "score": 0.4344
        },
        {
          "datasource": "eva_somatic",
          "score": 0.1824
        }
      ],
      "datatype_scores": [
        {
          "datatype": "literature",
          "score": 0.9984
        },
        {
          "datatype": "clinical",
          "score": 0.9778
        },
        {
          "datatype": "somatic_mutation",
          "score": 0.7964
        },
        {
          "datatype": "genetic_association",
          "score": 0.6991
        },
        {
          "datatype": "affected_pathway",
          "score": 0.4344
        }
      ],
      "disease_id": "MONDO_0005105",
      "disease_name": "melanoma",
      "ensembl_id": "ENSG00000157764",
      "score": 0.8195,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0005105",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "cancer or benign tumor"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "genomics_england",
          "score": 0.9486
        },
        {
          "datasource": "eva",
          "score": 0.9398
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "impc",
          "score": 0.3899
        },
        {
          "datasource": "europepmc",
          "score": 0.0122
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_association",
          "score": 0.9398
        },
        {
          "datatype": "genetic_literature",
          "score": 0.8804
        },
        {
          "datatype": "animal_model",
          "score": 0.3899
        },
        {
          "datatype": "literature",
          "score": 0.0122
        }
      ],
      "disease_id": "MONDO_0007265",
      "disease_name": "cardiofaciocutaneous syndrome 1",
      "ensembl_id": "ENSG00000157764",
      "score": 0.7636,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0007265",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "genetic, familial or congenital disease",
        "integumentary system disorder",
        "cardiovascular disorder",
        "musculoskeletal or connective tissue disease"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "genomics_england",
          "score": 0.9437
        },
        {
          "datasource": "eva",
          "score": 0.9316
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "impc",
          "score": 0.3302
        },
        {
          "datasource": "europepmc",
          "score": 0.0334
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_association",
          "score": 0.9316
        },
        {
          "datatype": "genetic_literature",
          "score": 0.8766
        },
        {
          "datatype": "animal_model",
          "score": 0.3302
        },
        {
          "datatype": "literature",
          "score": 0.0334
        }
      ],
      "disease_id": "MONDO_0013379",
      "disease_name": "Noonan syndrome 7",
      "ensembl_id": "ENSG00000157764",
      "score": 0.759,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0013379",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "cardiovascular disorder",
        "genetic, familial or congenital disease",
        "hematologic disorder",
        "integumentary system disorder",
        "immune system disorder",
        "musculoskeletal or connective tissue disease",
        "phenotype"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "genomics_england",
          "score": 0.9486
        },
        {
          "datasource": "eva",
          "score": 0.8914
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "impc",
          "score": 0.3629
        },
        {
          "datasource": "europepmc",
          "score": 0.0122
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_association",
          "score": 0.8914
        },
        {
          "datatype": "genetic_literature",
          "score": 0.8804
        },
        {
          "datatype": "animal_model",
          "score": 0.3629
        },
        {
          "datatype": "literature",
          "score": 0.0122
        }
      ],
      "disease_id": "MONDO_0013380",
      "disease_name": "LEOPARD syndrome 3",
      "ensembl_id": "ENSG00000157764",
      "score": 0.756,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0013380",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "genetic, familial or congenital disease",
        "cardiovascular disorder",
        "musculoskeletal or connective tissue disease"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "genomics_england",
          "score": 0.9501
        },
        {
          "datasource": "gene2phenotype",
          "score": 0.6079
        },
        {
          "datasource": "orphanet",
          "score": 0.6079
        },
        {
          "datasource": "uniprot_literature",
          "score": 0.6079
        },
        {
          "datasource": "uniprot_variants",
          "score": 0.6079
        },
        {
          "datasource": "impc",
          "score": 0.4205
        },
        {
          "datasource": "europepmc",
          "score": 0.1067
        },
        {
          "datasource": "clingen",
          "score": 0.0061
        },
        {
          "datasource": "eva",
          "score": 0
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_literature",
          "score": 0.8219
        },
        {
          "datatype": "genetic_association",
          "score": 0.5583
        },
        {
          "datatype": "animal_model",
          "score": 0.4205
        },
        {
          "datatype": "literature",
          "score": 0.1067
        }
      ],
      "disease_id": "MONDO_0007893",
      "disease_name": "Noonan syndrome with multiple lentigines",
      "ensembl_id": "ENSG00000157764",
      "score": 0.7507,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0007893",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "genetic, familial or congenital disease",
        "cardiovascular disorder",
        "musculoskeletal or connective tissue disease"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "europepmc",
          "score": 0.9698
        },
        {
          "datasource": "clinical_precedence",
          "score": 0.9408
        },
        {
          "datasource": "eva",
          "score": 0.8521
        },
        {
          "datasource": "uniprot_variants",
          "score": 0.4449
        },
        {
          "datasource": "impc",
          "score": 0.3137
        },
        {
          "datasource": "uniprot_literature",
          "score": 0.304
        }
      ],
      "datatype_scores": [
        {
          "datatype": "literature",
          "score": 0.9698
        },
        {
          "datatype": "clinical",
          "score": 0.9408
        },
        {
          "datatype": "genetic_association",
          "score": 0.7707
        },
        {
          "datatype": "animal_model",
          "score": 0.3137
        },
        {
          "datatype": "genetic_literature",
          "score": 0.304
        }
      ],
      "disease_id": "MONDO_0005575",
      "disease_name": "colorectal cancer",
      "ensembl_id": "ENSG00000157764",
      "score": 0.7489,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0005575",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "gastrointestinal disease",
        "cancer or benign tumor"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "europepmc",
          "score": 0.9856
        },
        {
          "datasource": "reactome",
          "score": 0.9834
        },
        {
          "datasource": "cancer_biomarkers",
          "score": 0.7599
        },
        {
          "datasource": "eva",
          "score": 0.4256
        },
        {
          "datasource": "clinical_precedence",
          "score": 0.423
        }
      ],
      "datatype_scores": [
        {
          "datatype": "literature",
          "score": 0.9856
        },
        {
          "datatype": "affected_pathway",
          "score": 0.9387
        },
        {
          "datatype": "genetic_association",
          "score": 0.4256
        },
        {
          "datatype": "clinical",
          "score": 0.423
        }
      ],
      "disease_id": "MONDO_0004992",
      "disease_name": "cancer",
      "ensembl_id": "ENSG00000157764",
      "score": 0.7103,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0004992",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "cancer or benign tumor"
      ]
    },
    {
      "datasource_scores": [
        {
          "datasource": "eva",
          "score": 0.8521
        },
        {
          "datasource": "europepmc",
          "score": 0.8095
        },
        {
          "datasource": "uniprot_variants",
          "score": 0.7599
        },
        {
          "datasource": "genomics_england",
          "score": 0.6079
        },
        {
          "datasource": "uniprot_literature",
          "score": 0.6079
        },
        {
          "datasource": "clinical_precedence",
          "score": 0.1794
        }
      ],
      "datatype_scores": [
        {
          "datatype": "genetic_association",
          "score": 0.8337
        },
        {
          "datatype": "literature",
          "score": 0.8095
        },
        {
          "datatype": "genetic_literature",
          "score": 0.6079
        },
        {
          "datatype": "clinical",
          "score": 0.1794
        }
      ],
      "disease_id": "MONDO_0008903",
      "disease_name": "lung cancer",
      "ensembl_id": "ENSG00000157764",
      "score": 0.7048,
      "source_url": "https://platform.opentargets.org/evidence/ENSG00000157764/MONDO_0008903",
      "symbol": "BRAF",
      "therapeutic_areas": [
        "respiratory or thoracic disease",
        "cancer or benign tumor",
        "phenotype"
      ]
    }
  ],
  "source_url": "https://platform.opentargets.org/target/ENSG00000157764/associations",
  "target": {
    "ensembl_id": "ENSG00000157764",
    "name": "B-Raf proto-oncogene, serine/threonine kinase",
    "symbol": "BRAF"
  },
  "therapeutic_area": null,
  "total_count": 2928
}

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