Firecrawl Alexandria

AlphaFold Protein Structure Database

AlphaFold DB, EMBL-EBI and Google DeepMind's database of over 260 million predicted protein structures, through its keyless API at alphafold.ebi.ac.uk: the predicted structure of a protein with its pLDDT confidence, the residue ranges that are confident and those likely disordered, and links to the model, PAE and confidence files; predicted complexes containing a protein with their partners and interface scores (ipTM, ipSAE, pDockQ); and AlphaMissense pathogenicity predictions for every possible missense substitution in a human protein. Takes UniProt accessions, entry names, AlphaFold model IDs, entry URLs or gene symbols. Data is CC BY 4.0: every result carries its licence, citations and entry page.

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AlphaFold Protein Structure Database
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1Request
string

Gene symbol (TP53, CD52, HLA-A), resolved to the one reviewed (Swiss-Prot) UniProt entry with that gene name, or that synonym, in organism. A symbol shared by several entries is invalid_input listing them.

string

UniProt accession (P04637), isoform (P04637-2), entry name (P53_HUMAN), AlphaFold DB model ID (AF-P04637-F1, AF-0000000000710001) or alphafold.ebi.ac.uk entry URL; case-insensitive. Exactly one of id and gene.

string

Organism for gene: NCBI taxonomy ID (9606) or name (human, Mus musculus). Default 9606 (human). Only with gene.

5 credits
Codefollows the fields above
const result = await firecrawl.scrape({
  alexandria: {
    provider: "alphafold-ebi-ac-uk",
    capability: "structures/prediction",
    options: {
      id: "P04637",
    },
  },
});
2Response example

This is a sample shape. Press Run to see live data from AlphaFold Protein Structure Database.

{
  "entry_name": "P53_HUMAN",
  "gene": "TP53",
  "license": {
    "attribution": "Data from the AlphaFold Protein Structure Database (alphafold.ebi.ac.uk), EMBL-EBI and Google DeepMind, CC BY 4.0. Cite Jumper J et al., Highly accurate protein structure prediction with AlphaFold, Nature 2021; Fleming J et al., AlphaFold Protein Structure Database and 3D-Beacons: New Data and Capabilities, J Mol Biol 2025, and the dataset publication named on the entry page for third-party predictions.",
    "name": "CC BY 4.0",
    "url": "https://creativecommons.org/licenses/by/4.0/"
  },
  "model": {
    "alphamissense": true,
    "confidence": {
      "confident": 0.071,
      "low": 0.104,
      "very_high": 0.527,
      "very_low": 0.298
    },
    "confident_regions": [
      {
        "end": 25,
        "length": 6,
        "mean_plddt": 73.8,
        "start": 20
      },
      {
        "end": 292,
        "length": 199,
        "mean_plddt": 95.3,
        "start": 94
      },
      {
        "end": 355,
        "length": 32,
        "mean_plddt": 91,
        "start": 324
      }
    ],
    "created": "2025-08-01",
    "disordered_regions": [
      {
        "end": 14,
        "length": 14,
        "mean_plddt": 44.5,
        "start": 1
      },
      {
        "end": 79,
        "length": 51,
        "mean_plddt": 42.8,
        "start": 29
      },
      {
        "end": 321,
        "length": 27,
        "mean_plddt": 45.2,
        "start": 295
      },
      {
        "end": 393,
        "length": 36,
        "mean_plddt": 43,
        "start": 358
      }
    ],
    "files": {
      "bcif": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-model_v6.bcif",
      "cif": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-model_v6.cif",
      "pae_image": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-predicted_aligned_error_v6.png",
      "pae_json": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-predicted_aligned_error_v6.json",
      "pdb": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-model_v6.pdb",
      "plddt_json": "https://alphafold.ebi.ac.uk/files/AF-P04637-F1-confidence_v6.json"
    },
    "length": 393,
    "mean_plddt": 75.06,
    "method": "AlphaFold Monomer v2.0 pipeline",
    "model_id": "AF-P04637-F1",
    "provider": "Google DeepMind",
    "reading": "Mean pLDDT 75.1: 53% of residues very high confidence, 7% confident, 10% low and 30% very low (likely disordered).",
    "sequence_version_date": "2009-11-24",
    "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-F1",
    "uniprot_accession": "P04637",
    "uniprot_end": 393,
    "uniprot_start": 1,
    "version": 6,
    "versions": [
      1,
      2,
      3,
      4,
      5,
      6
    ]
  },
  "no_model_reason": null,
  "observed_at_ms": 1792534178966,
  "organism": {
    "name": "Homo sapiens",
    "taxon_id": 9606
  },
  "other_models": [
    {
      "length": 341,
      "mean_plddt": 76.94,
      "model_id": "AF-P04637-2-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-2-F1",
      "uniprot_accession": "P04637-2"
    },
    {
      "length": 346,
      "mean_plddt": 76.94,
      "model_id": "AF-P04637-3-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-3-F1",
      "uniprot_accession": "P04637-3"
    },
    {
      "length": 354,
      "mean_plddt": 77.81,
      "model_id": "AF-P04637-4-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-4-F1",
      "uniprot_accession": "P04637-4"
    },
    {
      "length": 302,
      "mean_plddt": 81.5,
      "model_id": "AF-P04637-5-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-5-F1",
      "uniprot_accession": "P04637-5"
    },
    {
      "length": 307,
      "mean_plddt": 82.44,
      "model_id": "AF-P04637-6-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-6-F1",
      "uniprot_accession": "P04637-6"
    },
    {
      "length": 261,
      "mean_plddt": 81.44,
      "model_id": "AF-P04637-7-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-7-F1",
      "uniprot_accession": "P04637-7"
    },
    {
      "length": 209,
      "mean_plddt": 83.56,
      "model_id": "AF-P04637-8-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-8-F1",
      "uniprot_accession": "P04637-8"
    },
    {
      "length": 214,
      "mean_plddt": 82.94,
      "model_id": "AF-P04637-9-F1",
      "provider": "Google DeepMind",
      "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-9-F1",
      "uniprot_accession": "P04637-9"
    }
  ],
  "protein_name": "Cellular tumor antigen p53",
  "reference_proteome": true,
  "requested": "P04637",
  "resolved_via": null,
  "reviewed": true,
  "source_url": "https://alphafold.ebi.ac.uk/entry/AF-P04637-F1",
  "uniprot_accession": "P04637"
}
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