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UniProt

UniProtKB, the UniProt Consortium's protein knowledgebase (EMBL-EBI, SIB and PIR), through its public REST API at rest.uniprot.org: search entries by text, gene, organism and Swiss-Prot review status; read one entry's protein and gene names with synonyms, organism, curated function, subcellular location with evidence codes, GO terms, disease associations, sequence length and PDB, AlphaFold, ChEMBL, Ensembl, NCBI Gene and HGNC cross-references; and map gene symbols or Ensembl, NCBI Gene, PDB and ChEMBL IDs to accessions. Data is CC BY 4.0: every result carries its license, attribution and entry URL.

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Where in the cell is human CD52 located, and on what evidence?

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const result = await firecrawl.scrape({
  alexandria: {
    provider: "uniprot-org",
    capability: "proteins/get",
    options: {
      accession: "P31358",
    },
  },
});

2Response example

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{
  "accession": "P31358",
  "annotation_score": 5,
  "cross_references": {
    "alphafold": [
      "P31358"
    ],
    "chembl": [
      "CHEMBL1912"
    ],
    "ensembl": [
      {
        "gene": "ENSG00000169442.9",
        "isoform": null,
        "protein": "ENSP00000363330.2",
        "transcript": "ENST00000374213.3"
      }
    ],
    "hgnc": [
      "HGNC:1804"
    ],
    "ncbi_gene": [
      "1043"
    ],
    "pdb": [
      {
        "chains": "E/F=27-36",
        "id": "6OBD",
        "method": "X-ray",
        "resolution": "2.20 A"
      }
    ]
  },
  "diseases": [],
  "ec_numbers": [],
  "entry_name": "CD52_HUMAN",
  "entry_version": 189,
  "function": [
    {
      "evidence": [],
      "text": "May play a role in carrying and orienting carbohydrate, as well as having a more specific role"
    }
  ],
  "gene_name": "CD52",
  "gene_synonyms": [
    "CDW52",
    "HE5"
  ],
  "genes": [
    {
      "name": "CD52",
      "ordered_locus_names": [],
      "orf_names": [],
      "synonyms": [
        "CDW52",
        "HE5"
      ]
    }
  ],
  "go_terms": [
    {
      "aspect": "cellular_component",
      "assigned_by": "Reactome",
      "evidence": [],
      "evidence_code": "TAS",
      "id": "GO:0005576",
      "term": "extracellular region"
    },
    {
      "aspect": "cellular_component",
      "assigned_by": "ProtInc",
      "evidence": [
        {
          "assertion": "manual",
          "code": "ECO:0000304",
          "id": "1711975",
          "label": "Traceable author statement evidence",
          "source": "PubMed"
        }
      ],
      "evidence_code": "TAS",
      "id": "GO:0016020",
      "term": "membrane"
    },
    {
      "aspect": "cellular_component",
      "assigned_by": "UniProtKB",
      "evidence": [
        {
          "assertion": "manual",
          "code": "ECO:0000304",
          "id": "1711975",
          "label": "Traceable author statement evidence",
          "source": "PubMed"
        }
      ],
      "evidence_code": "TAS",
      "id": "GO:0005886",
      "term": "plasma membrane"
    },
    {
      "aspect": "cellular_component",
      "assigned_by": "GO_Central",
      "evidence": [],
      "evidence_code": "IBA",
      "id": "GO:0097225",
      "term": "sperm midpiece"
    },
    {
      "aspect": "biological_process",
      "assigned_by": "UniProtKB",
      "evidence": [
        {
          "assertion": "manual",
          "code": "ECO:0000314",
          "id": "8223854",
          "label": "Direct assay evidence",
          "source": "PubMed"
        }
      ],
      "evidence_code": "IDA",
      "id": "GO:0007204",
      "term": "positive regulation of cytosolic calcium ion concentration"
    },
    {
      "aspect": "biological_process",
      "assigned_by": "UniProtKB",
      "evidence": [
        {
          "assertion": "manual",
          "code": "ECO:0000303",
          "id": "8223854",
          "label": "Non-traceable author statement evidence",
          "source": "PubMed"
        }
      ],
      "evidence_code": "NAS",
      "id": "GO:0045730",
      "term": "respiratory burst"
    }
  ],
  "last_annotation_update": "2026-09-02",
  "license": {
    "attribution": "UniProt Consortium, UniProtKB release 2026_03 (https://www.uniprot.org), licensed under CC BY 4.0",
    "name": "CC BY 4.0",
    "url": "https://creativecommons.org/licenses/by/4.0/"
  },
  "observed_at_ms": 1792447176156,
  "organism": {
    "common_name": "Human",
    "lineage": [
      "Eukaryota",
      "Metazoa",
      "Chordata",
      "Craniata",
      "Vertebrata",
      "Euteleostomi",
      "Mammalia",
      "Eutheria",
      "Euarchontoglires",
      "Primates",
      "Haplorrhini",
      "Catarrhini",
      "Hominidae",
      "Homo"
    ],
    "scientific_name": "Homo sapiens",
    "taxon_id": 9606
  },
  "protein_existence": "1: Evidence at protein level",
  "protein_name": "CAMPATH-1 antigen",
  "protein_name_source": "recommended",
  "protein_synonyms": [
    "CDw52",
    "Cambridge pathology 1 antigen",
    "Epididymal secretory protein E5",
    "Human epididymis-specific protein 5",
    "He5",
    "CD52"
  ],
  "release": "2026_03",
  "release_date": "02-September-2026",
  "requested_id": "P31358",
  "reviewed": true,
  "sequence": {
    "length": 61,
    "mass_da": 6614
  },
  "source_url": "https://www.uniprot.org/uniprotkb/P31358/entry",
  "subcellular_location": [
    {
      "locations": [
        {
          "evidence": [],
          "location": "Cell membrane",
          "location_id": "SL-0039",
          "orientation": null,
          "topology": "Lipid-anchor, GPI-anchor"
        }
      ],
      "molecule": null,
      "note": null,
      "note_evidence": []
    }
  ],
  "subcellular_locations": [
    "Cell membrane"
  ]
}

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