Firecrawl Alexandria
NCBI Gene
NCBI Gene, the U.S. National Center for Biotechnology Information's database of genes across organisms: search genes by symbol, name or Entrez query; read one gene's official symbol and aliases, NCBI summary with who provided it, chromosome and genomic location, RefSeq and MANE Select transcripts, GeneRIF publications and UniProt, Ensembl, HGNC and OMIM cross-references; and list its orthologs in other species. Uses the NCBI Datasets v2 API and E-utilities anonymously. NCBI places no restrictions on the data; every output carries an attribution line and gene page URLs.
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const result = await firecrawl.scrape({
alexandria: {
provider: "gene-ncbi-nlm-nih-gov",
capability: "genes/get",
options: {
gene_id: "7157",
},
},
});2Response example
This is a sample shape. Press Run to see live data from NCBI Gene.
{
"candidates": [],
"gene": {
"aliases": [
"P53",
"BCC7",
"LFS1",
"BMFS5",
"TRP53"
],
"chromosomes": [
"17"
],
"ensembl_gene_ids": [
"ENSG00000141510"
],
"gene_id": "7157",
"generifs": {
"count": 9982,
"pmids": [
"39469578",
"39454005",
"39436667",
"39390510",
"39368467",
"39324446",
"39321806",
"39312196",
"39289671",
"39283177",
"39242607",
"39207627",
"39173856",
"39148095",
"39134014",
"39126833",
"39074355",
"39062707",
"39060302",
"39018356"
]
},
"genomic_locations": [
{
"assembly": "GRCh38.p14",
"assembly_accession": "GCF_000001405.40",
"end": 7687490,
"sequence_accession": "NC_000017.11",
"sequence_name": "17",
"start": 7668421,
"strand": "minus"
},
{
"assembly": "T2T-CHM13v2.0",
"assembly_accession": "GCF_009914755.1",
"end": 7591594,
"sequence_accession": "NC_060941.1",
"sequence_name": "17",
"start": 7572544,
"strand": "minus"
}
],
"locus_tag": null,
"map_location": "17p13.1",
"name": "tumor protein p53",
"nomenclature": {
"authority": "HGNC",
"id": "HGNC:11998"
},
"omim_ids": [
"191170"
],
"organism": {
"common_name": "human",
"scientific_name": "Homo sapiens",
"taxon_id": 9606
},
"other_names": [
"antigen NY-CO-13",
"cellular tumor antigen p53",
"mutant tumor protein 53",
"phosphoprotein p53",
"transformation-related protein 53",
"tumor protein 53",
"tumor supressor p53"
],
"refseq": {
"gene": "NG_017013.2",
"protein_count": 25,
"select_transcript": {
"accession": "NM_000546.6",
"ensembl_protein": "ENSP00000269305.4",
"ensembl_transcript": "ENST00000269305.9",
"name": "transcript variant 1",
"protein": "NP_000537.3",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": "mane_select",
"type": "protein_coding"
},
"transcript_count": 26,
"transcripts": [
{
"accession": "NM_000546.6",
"ensembl_protein": "ENSP00000269305.4",
"ensembl_transcript": "ENST00000269305.9",
"name": "transcript variant 1",
"protein": "NP_000537.3",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": "mane_select",
"type": "protein_coding"
},
{
"accession": "NM_001126112.3",
"ensembl_protein": "ENSP00000391478.2",
"ensembl_transcript": "ENST00000445888.7",
"name": "transcript variant 2",
"protein": "NP_001119584.1",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126113.3",
"ensembl_protein": "ENSP00000398846.2",
"ensembl_transcript": "ENST00000455263.7",
"name": "transcript variant 4",
"protein": "NP_001119585.1",
"protein_name": "cellular tumor antigen p53 isoform c",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126114.3",
"ensembl_protein": "ENSP00000391127.2",
"ensembl_transcript": "ENST00000420246.7",
"name": "transcript variant 3",
"protein": "NP_001119586.1",
"protein_name": "cellular tumor antigen p53 isoform b",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126115.2",
"ensembl_protein": "ENSP00000481179.1",
"ensembl_transcript": "ENST00000504937.5",
"name": "transcript variant 5",
"protein": "NP_001119587.1",
"protein_name": "cellular tumor antigen p53 isoform d",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126116.2",
"ensembl_protein": "ENSP00000478499.1",
"ensembl_transcript": "ENST00000510385.5",
"name": "transcript variant 6",
"protein": "NP_001119588.1",
"protein_name": "cellular tumor antigen p53 isoform e",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126117.2",
"ensembl_protein": "ENSP00000484409.1",
"ensembl_transcript": "ENST00000504290.5",
"name": "transcript variant 7",
"protein": "NP_001119589.1",
"protein_name": "cellular tumor antigen p53 isoform f",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001126118.2",
"ensembl_protein": "ENSP00000478219.1",
"ensembl_transcript": "ENST00000610292.4",
"name": "transcript variant 8",
"protein": "NP_001119590.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276695.3",
"ensembl_protein": "ENSP00000480868.1",
"ensembl_transcript": "ENST00000610538.4",
"name": "transcript variant 4",
"protein": "NP_001263624.1",
"protein_name": "cellular tumor antigen p53 isoform h",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276696.3",
"ensembl_protein": "ENSP00000482222.1",
"ensembl_transcript": "ENST00000622645.4",
"name": "transcript variant 3",
"protein": "NP_001263625.1",
"protein_name": "cellular tumor antigen p53 isoform i",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276697.3",
"ensembl_protein": "ENSP00000484375.1",
"ensembl_transcript": "ENST00000619186.4",
"name": "transcript variant 5",
"protein": "NP_001263626.1",
"protein_name": "cellular tumor antigen p53 isoform j",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276698.3",
"ensembl_protein": "ENSP00000481401.1",
"ensembl_transcript": "ENST00000618944.4",
"name": "transcript variant 6",
"protein": "NP_001263627.1",
"protein_name": "cellular tumor antigen p53 isoform k",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276699.3",
"ensembl_protein": "ENSP00000477531.1",
"ensembl_transcript": "ENST00000610623.4",
"name": "transcript variant 7",
"protein": "NP_001263628.1",
"protein_name": "cellular tumor antigen p53 isoform l",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276760.3",
"ensembl_protein": "ENSP00000481638.1",
"ensembl_transcript": "ENST00000620739.4",
"name": "transcript variant 1",
"protein": "NP_001263689.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001276761.3",
"ensembl_protein": "ENSP00000482537.1",
"ensembl_transcript": "ENST00000619485.4",
"name": "transcript variant 2",
"protein": "NP_001263690.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407262.1",
"ensembl_protein": "ENSP00000426252.2",
"ensembl_transcript": "ENST00000503591.3",
"name": "transcript variant 9",
"protein": "NP_001394191.1",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407263.1",
"ensembl_protein": null,
"ensembl_transcript": null,
"name": "transcript variant 9",
"protein": "NP_001394192.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407264.1",
"ensembl_protein": "ENSP00000593626.1",
"ensembl_transcript": "ENST00000923567.2",
"name": "transcript variant 10",
"protein": "NP_001394193.1",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407265.1",
"ensembl_protein": null,
"ensembl_transcript": null,
"name": "transcript variant 10",
"protein": "NP_001394194.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407266.1",
"ensembl_protein": "ENSP00000424104.2",
"ensembl_transcript": "ENST00000508793.6",
"name": "transcript variant 11",
"protein": "NP_001394195.1",
"protein_name": "cellular tumor antigen p53 isoform a",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407267.1",
"ensembl_protein": null,
"ensembl_transcript": null,
"name": "transcript variant 11",
"protein": "NP_001394196.1",
"protein_name": "cellular tumor antigen p53 isoform g",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407268.1",
"ensembl_protein": "ENSP00000352610.4",
"ensembl_transcript": "ENST00000359597.8",
"name": "transcript variant 12",
"protein": "NP_001394197.1",
"protein_name": "cellular tumor antigen p53 isoform b",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407269.1",
"ensembl_protein": null,
"ensembl_transcript": null,
"name": "transcript variant 12",
"protein": "NP_001394198.1",
"protein_name": "cellular tumor antigen p53 isoform i",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407270.1",
"ensembl_protein": "ENSP00000745782.1",
"ensembl_transcript": "ENST00001075976.1",
"name": "transcript variant 13",
"protein": "NP_001394199.1",
"protein_name": "cellular tumor antigen p53 isoform b",
"select_category": null,
"type": "protein_coding"
},
{
"accession": "NM_001407271.1",
"ensembl_protein": null,
"ensembl_transcript": null,
"name": "transcript variant 13",
"protein": "NP_001394200.1",
"protein_name": "cellular tumor antigen p53 isoform i",
"select_category": null,
"type": "protein_coding"
}
]
},
"source_url": "https://www.ncbi.nlm.nih.gov/gene/7157",
"summary": {
"date": "2016-12",
"provided_by": "RefSeq",
"text": "This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]"
},
"symbol": "TP53",
"type": "protein_coding",
"uniprot_ids": [
"P04637"
]
},
"license": {
"attribution": "Data from NCBI Gene, National Center for Biotechnology Information, U.S. National Library of Medicine (https://www.ncbi.nlm.nih.gov/gene/).",
"name": "Public domain (NCBI)",
"url": "https://www.ncbi.nlm.nih.gov/home/about/policies/"
},
"observed_at_ms": 1792529971704,
"resolution": {
"gene_id": "7157",
"input": "7157",
"matched_on": "gene_id",
"note": null,
"organism": null,
"replaced_gene_id": null
}
}